HSD3B1 and response to a nonsteroidal CYP17A1 inhibitor in castration-resistant prostate cancer
N Almassi, C Reichard, J Li, C Russell, J Perry… - JAMA …, 2018 - jamanetwork.com
Importance TheHSD3B1 (1245C) germline variant encodes for a gain-of-function missense
in 3β-hydroxysteroid dehydrogenase isoenzyme 1 (3βHSD1) that results in increased
dihydrotestosterone synthesis from extragonadal precursors and is predictive of more rapid
progression to castration-resistant prostate cancer (CRPC). Objective To determine whether
theHSD3B1 (1245C) genotype is predictive of clinical response to extragonadal androgen
ablation with nonsteroidal 17α-hydroxylase/17, 20-lyase (CYP17A1) inhibition in men with …
in 3β-hydroxysteroid dehydrogenase isoenzyme 1 (3βHSD1) that results in increased
dihydrotestosterone synthesis from extragonadal precursors and is predictive of more rapid
progression to castration-resistant prostate cancer (CRPC). Objective To determine whether
theHSD3B1 (1245C) genotype is predictive of clinical response to extragonadal androgen
ablation with nonsteroidal 17α-hydroxylase/17, 20-lyase (CYP17A1) inhibition in men with …
