[HTML][HTML] The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C
The transporters for serotonin (SERT), dopamine, and noradrenaline have a conserved
hydrophobic core but divergent N and C termini. The C terminus harbors the binding site for
the coat protein complex II (COPII) cargo-binding protein SEC24. Here we explored which
SEC24 isoform was required for export of SERT from the endoplasmic reticulum (ER). Three
lines of evidence argue that SERT can only exit the ER by recruiting SEC24C:(i) Mass
spectrometry showed that a peptide corresponding to the C terminus of SERT recruited …
hydrophobic core but divergent N and C termini. The C terminus harbors the binding site for
the coat protein complex II (COPII) cargo-binding protein SEC24. Here we explored which
SEC24 isoform was required for export of SERT from the endoplasmic reticulum (ER). Three
lines of evidence argue that SERT can only exit the ER by recruiting SEC24C:(i) Mass
spectrometry showed that a peptide corresponding to the C terminus of SERT recruited …