Successful hematopoietic stem cell transplantation for myelofibrosis in an adult with warts-hypogammaglobulinemia-immunodeficiency-myelokathexis syndrome

L Moens, G Frans, B Bosch, X Bossuyt… - Journal of Allergy and …, 2016 - jacionline.org
LETTERS TO THE EDITOR 1485 hypogammaglobulinemia, and refractory human
papillomavirus (HPV) infections. Contrasting with the neutropenia, abundant mature
neutrophils with hypersegmented nuclei are retained in the bone marrow, a phenomenon
named myelokathexis. Most cases of WHIM syndrome are caused by gain-of-function
mutations in the CXC chemokine receptor type 4 (CXCR4). CXCR4 was first studied as a
cell surface receptor for HIV. The interaction with its ligand, stromal cell–derived factor 1 or …