[PDF][PDF] The glioblastoma vasculature as a target for cancer therapy.
A Dimberg - Biochemical Society Transactions, 2014 - Citeseer
A Dimberg
Biochemical Society Transactions, 2014•CiteseerGlioblastoma is characterized by microvascular proliferation and a highly abnormal
dysfunctional vasculature. The glioblastoma vessels differ significantly from normal brain
vessels morphologically, functionally and molecularly. The present review provides a brief
overview of the current understanding of the formation, functional abnormalities and specific
gene expression of glioblastoma vessels and the consequences of vascular
abnormalization for the tumour microenvironment.
dysfunctional vasculature. The glioblastoma vessels differ significantly from normal brain
vessels morphologically, functionally and molecularly. The present review provides a brief
overview of the current understanding of the formation, functional abnormalities and specific
gene expression of glioblastoma vessels and the consequences of vascular
abnormalization for the tumour microenvironment.
Abstract
Glioblastoma is characterized by microvascular proliferation and a highly abnormal dysfunctional vasculature. The glioblastoma vessels differ significantly from normal brain vessels morphologically, functionally and molecularly. The present review provides a brief overview of the current understanding of the formation, functional abnormalities and specific gene expression of glioblastoma vessels and the consequences of vascular abnormalization for the tumour microenvironment.
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