[HTML][HTML] Structurally related Spc1p and Spc2p of yeast signal peptidase complex are functionally distinct
C Mullins, HA Meyer, E Hartmann, N Green… - Journal of Biological …, 1996 - ASBMB
Two subunits of the mammalian signal peptidase complex, SPC12 and SPC25, share
similar membrane topologies with the majority of each protein oriented toward the
cytoplasm. Such similarities may suggest that these proteins perform redundant functions in
signal peptidase activity. In the present study, we addressed this issue through analysis of
the yeast homologs to SPC12 and SPC25, Spc1p and Spc2p. We show that both Spc1p and
Spc2p are nonessential for signal peptidase activity and growth of yeast cells and that null …
similar membrane topologies with the majority of each protein oriented toward the
cytoplasm. Such similarities may suggest that these proteins perform redundant functions in
signal peptidase activity. In the present study, we addressed this issue through analysis of
the yeast homologs to SPC12 and SPC25, Spc1p and Spc2p. We show that both Spc1p and
Spc2p are nonessential for signal peptidase activity and growth of yeast cells and that null …