[HTML][HTML] Direct interaction of CaVβ with actin up-regulates L-type calcium currents in HL-1 cardiomyocytes

G Stölting, RC de Oliveira, RE Guzman… - Journal of Biological …, 2015 - ASBMB
Expression of the β-subunit (Ca V β) is required for normal function of cardiac L-type calcium
channels, and its up-regulation is associated with heart failure. Ca V β binds to the α 1 pore-
forming subunit of L-type channels and augments calcium current density by facilitating
channel opening and increasing the number of channels in the plasma membrane, by a
poorly understood mechanism. Actin, a key component of the intracellular trafficking
machinery, interacts with Src homology 3 domains in different proteins. Although Ca V β …