[HTML][HTML] Binding of hyaluronan to the native lymphatic vessel endothelial receptor LYVE-1 is critically dependent on receptor clustering and hyaluronan organization
W Lawrance, S Banerji, AJ Day, S Bhattacharjee… - Journal of Biological …, 2016 - ASBMB
The lymphatic endothelial receptor LYVE-1 has been implicated in both uptake of
hyaluronan (HA) from tissue matrix and in facilitating transit of leukocytes and tumor cells
through lymphatic vessels based largely on in vitro studies with recombinant receptor in
transfected fibroblasts. Curiously, however, LYVE-1 in lymphatic endothelium displays little if
any binding to HA in vitro, and this has led to the conclusion that the native receptor is
functionally silenced, a feature that is difficult to reconcile with its proposed in vivo functions …
hyaluronan (HA) from tissue matrix and in facilitating transit of leukocytes and tumor cells
through lymphatic vessels based largely on in vitro studies with recombinant receptor in
transfected fibroblasts. Curiously, however, LYVE-1 in lymphatic endothelium displays little if
any binding to HA in vitro, and this has led to the conclusion that the native receptor is
functionally silenced, a feature that is difficult to reconcile with its proposed in vivo functions …