Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins
NA Petasis, I Akritopoulou-Zanze, VV Fokin… - … and essential fatty acids, 2005 - Elsevier
The lipoxins (LX) are a class of potent endogenous oxygenated products that are
enzymatically generated from arachidonic acid and have novel anti-inflammatory properties
and promote resolution. Elucidation of the biochemical pathways involved in the metabolic
inactivation of LX and the discovery of the aspirin-triggered lipoxins (ATL) provided the basis
for the design and synthesis of stable analogs of LX and ATL. This special issue review
describes the efforts that led to the design and synthesis of stable LX/ATL mimetics, which …
enzymatically generated from arachidonic acid and have novel anti-inflammatory properties
and promote resolution. Elucidation of the biochemical pathways involved in the metabolic
inactivation of LX and the discovery of the aspirin-triggered lipoxins (ATL) provided the basis
for the design and synthesis of stable analogs of LX and ATL. This special issue review
describes the efforts that led to the design and synthesis of stable LX/ATL mimetics, which …