Sox9-dependent acinar-to-ductal reprogramming is critical for pancreatic intraepithelial neoplasia formation
A Fukuda, T Chiba - Gastroenterology, 2013 - gastrojournal.org
Pancreatic ductal adenocarcinoma (PDA) is characterized by a dismal prognosis in all
human malignancies, and the incidence of this disease is increasing. Therefore, new
methods for early detection of PDA and novel approaches for prevention and treatment of
the disease are required. To establish a new therapy, it is important to understand the
biology of PDA, including the mechanisms involved in PDA initiation events. PDA is
assumed to arise from 3 morphologically different precursor lesions: Pancreatic …
human malignancies, and the incidence of this disease is increasing. Therefore, new
methods for early detection of PDA and novel approaches for prevention and treatment of
the disease are required. To establish a new therapy, it is important to understand the
biology of PDA, including the mechanisms involved in PDA initiation events. PDA is
assumed to arise from 3 morphologically different precursor lesions: Pancreatic …