Purinergic signaling has been recognized as playing an important role in inflammation,
angiogenesis, malignancy, diabetes and neural transmission. Activation of signaling
pathways downstream from purinergic receptors may also be implicated in transplantation
and related vascular injury. Following transplantation, the proinflammatory “danger signal”
adenosine triphosphate (ATP) is released from damaged cells and promotes proliferation
and activation of a variety of immune cells. Targeting purinergic signaling pathways may …