[HTML][HTML] Th17 responses to collagen type V, kα1-tubulin, and vimentin are present early in human development and persist throughout life
JA Sullivan, E Jankowska-Gan, S Hegde… - American Journal of …, 2017 - Elsevier
T helper 17 (Th17)–dependent autoimmune responses can develop after heart or lung
transplantation and are associated with fibro-obliterative forms of chronic rejection; however,
the specific self-antigens involved are typically different from those associated with
autoimmune disease. To investigate the basis of these responses, we investigated whether
removal of regulatory T cells or blockade of function reveals a similar autoantigen bias. We
found that Th17 cells specific for collagen type V (Col V), kα1-tubulin, and vimentin were …
transplantation and are associated with fibro-obliterative forms of chronic rejection; however,
the specific self-antigens involved are typically different from those associated with
autoimmune disease. To investigate the basis of these responses, we investigated whether
removal of regulatory T cells or blockade of function reveals a similar autoantigen bias. We
found that Th17 cells specific for collagen type V (Col V), kα1-tubulin, and vimentin were …