[HTML][HTML] Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance

EÁ Hernández, S Kahl, A Seelig… - The Journal of …, 2017 - Am Soc Clin Investig
EÁ Hernández, S Kahl, A Seelig, P Begovatz, M Irmler, Y Kupriyanova, B Nowotny…
The Journal of clinical investigation, 2017Am Soc Clin Investig
Nonalcoholic fatty liver disease (NAFLD) is characterized by excess accumulation of fat in
the liver. In some cases, NAFLD is also accompanied by insulin resistance, resulting in
metabolic dysfunction. Dietary fat content probably influences both NAFLD and insulin
resistance; however, the immediate effects of fat consumption have not been fully explored.
In this issue of the JCI, Hernández et al. evaluated hepatic glucose and lipid metabolism in
humans and mice following a single oral dose of saturated fat. This one bolus of fat resulted …
Abstract
Nonalcoholic fatty liver disease (NAFLD) is characterized by excess accumulation of fat in the liver. In some cases, NAFLD is also accompanied by insulin resistance, resulting in metabolic dysfunction. Dietary fat content probably influences both NAFLD and insulin resistance; however, the immediate effects of fat consumption have not been fully explored. In this issue of the JCI, Hernández et al. evaluated hepatic glucose and lipid metabolism in humans and mice following a single oral dose of saturated fat. This one bolus of fat resulted in a measurable increase in insulin resistance, hepatic triglycerides, and gluconeogenesis. In mice, the saturated fat bolus resulted in the induction of several NAFLD-associated genes. Together, the results of this study indicate that saturated fat intake has immediate effects on metabolic function.
The Journal of Clinical Investigation