The liver diseases of lipodystrophy: the long-term effect of leptin treatment
ES Zadeh, AO Lungu, EK Cochran, RJ Brown… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: Lipodystrophies are hypoleptinemic conditions characterized by fat
loss, severe insulin resistance, hypertriglyceridemia, and ectopic fat accumulation. Non-
alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) are also features of this
condition. We studied the spectrum of liver disease in lipodystrophy and the effects of leptin
replacement. METHODS: This was an open-label, prospective study of leptin therapy in
patients with inherited and acquired lipodystrophy at the National Institutes of Health. Liver …
loss, severe insulin resistance, hypertriglyceridemia, and ectopic fat accumulation. Non-
alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) are also features of this
condition. We studied the spectrum of liver disease in lipodystrophy and the effects of leptin
replacement. METHODS: This was an open-label, prospective study of leptin therapy in
patients with inherited and acquired lipodystrophy at the National Institutes of Health. Liver …