[HTML][HTML] Lactosylceramide Stimulates Ras-GTP Loading, Kinases (MEK, Raf), p44 Mitogen-activated Protein Kinase, and c-fos Expression in Human Aortic Smooth …
AK Bhunia, H Han, A Snowden, S Chatterjee - Journal of Biological …, 1996 - ASBMB
Previously, our laboratory has shown that lactosylceramide (LacCer) can serve as a
mitogenic agent in the proliferation of aortic smooth muscle cells" a hallmark in the
pathogenesis of atherosclerosis"(Chatterjee, S.(1991) Biochem. Biophys. Res. Commun.
181, 554-561). Here we report a novel aspect of LacCer-mediated signal transduction. We
demonstrate that LacCer (10 μM) can stimulate the phosphorylation of mitogen-activated
protein (MAP) kinase p44 MAPK to phosphorylated p44 MAPK in aortic smooth muscle cells …
mitogenic agent in the proliferation of aortic smooth muscle cells" a hallmark in the
pathogenesis of atherosclerosis"(Chatterjee, S.(1991) Biochem. Biophys. Res. Commun.
181, 554-561). Here we report a novel aspect of LacCer-mediated signal transduction. We
demonstrate that LacCer (10 μM) can stimulate the phosphorylation of mitogen-activated
protein (MAP) kinase p44 MAPK to phosphorylated p44 MAPK in aortic smooth muscle cells …
