[HTML][HTML] Ectodomain lysines and suramin block of P2X1 receptors
JA Sim, HE Broomhead, RA North - Journal of biological chemistry, 2008 - ASBMB
P2X 1 receptors belong to a family of cation channels gated by extracellular ATP; they are
found inter alia in smooth muscle, platelets, and immune cells. Suramin has been widely
used as an antagonist at P2X receptors, and its analog 4, 4′, 4 ″, 4‴-[carbonylbis (imino-
5, 1, 3-benzenetriylbis (carbonylimino))] tetrakis-benzene-1, 3-disulfonic acid (NF449) is
selective for the P2X 1 subtype. Human and mouse P2X 1 receptors were expressed in
human embryonic kidney cells, and membrane currents evoked by ATP were recorded. ATP …
found inter alia in smooth muscle, platelets, and immune cells. Suramin has been widely
used as an antagonist at P2X receptors, and its analog 4, 4′, 4 ″, 4‴-[carbonylbis (imino-
5, 1, 3-benzenetriylbis (carbonylimino))] tetrakis-benzene-1, 3-disulfonic acid (NF449) is
selective for the P2X 1 subtype. Human and mouse P2X 1 receptors were expressed in
human embryonic kidney cells, and membrane currents evoked by ATP were recorded. ATP …