[HTML][HTML] Pirfenidone inhibits lung allograft fibrosis through L-arginine–arginase pathway
H Liu, P Drew, AC Gaugler, Y Cheng… - American Journal of …, 2005 - Elsevier
Transplant-related lung fibrosis is characterized by excessive fibro-collagenous deposition.
Induction of arginase, an enzyme that metabolizes L-arginine to urea and L-ornithine, is vital
for collagen synthesis. Pirfenidone is an investigational anti-fibrotic agent shown to be
effective in blocking pulmonary fibrosis. The purpose of this study was to determine if
pirfenidone was protective against the development of fibro-collagenous injury in rat lung
orthotopic transplants through altering L-arginine–arginase metabolic pathways. Lung …
Induction of arginase, an enzyme that metabolizes L-arginine to urea and L-ornithine, is vital
for collagen synthesis. Pirfenidone is an investigational anti-fibrotic agent shown to be
effective in blocking pulmonary fibrosis. The purpose of this study was to determine if
pirfenidone was protective against the development of fibro-collagenous injury in rat lung
orthotopic transplants through altering L-arginine–arginase metabolic pathways. Lung …