Tumour necrosis factor (TNF) in psoriatic arthritis: pathophysiology and treatment with TNF inhibitors

PJ Mease - Annals of the rheumatic diseases, 2002 - ard.bmj.com
PJ Mease
Annals of the rheumatic diseases, 2002ard.bmj.com
High levels of proinflammatory cytokines, including tumour necrosis factor (TNF), have been
detected in psoriatic skin lesions and joints of patients with the inflammatory disease. Early
results of treatment of psoriatic arthritis and psoriasis with TNF neutralising agents are
encouraging, but whether these agents will be able to improve long term outcomes, such as
disability, is not yet known.
High levels of proinflammatory cytokines, including tumour necrosis factor (TNF), have been detected in psoriatic skin lesions and joints of patients with the inflammatory disease. Early results of treatment of psoriatic arthritis and psoriasis with TNF neutralising agents are encouraging, but whether these agents will be able to improve long term outcomes, such as disability, is not yet known.
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