[HTML][HTML] TGIF2 interacts with histone deacetylase 1 and represses transcription
TA Melhuish, CM Gallo, D Wotton - Journal of Biological Chemistry, 2001 - ASBMB
TG-interacting factor (TGIF) is a transcriptional repressor, which represses transcription by
binding directly to DNA or interacts with transforming growth factor β (TGFβ)-activated
Smads, thereby repressing TGFβ-responsive gene expression. Mutation of TGIF in humans
causes holoprosencephaly, a severe genetic disorder affecting craniofacial development.
Searching human expressed sequence tag data bases revealed the presence of clones
encoding a TGIF-related protein (TGIF2), which contains two regions of high sequence …
binding directly to DNA or interacts with transforming growth factor β (TGFβ)-activated
Smads, thereby repressing TGFβ-responsive gene expression. Mutation of TGIF in humans
causes holoprosencephaly, a severe genetic disorder affecting craniofacial development.
Searching human expressed sequence tag data bases revealed the presence of clones
encoding a TGIF-related protein (TGIF2), which contains two regions of high sequence …