[HTML][HTML] Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox …
SM Beer, ER Taylor, SE Brown, CC Dahm… - Journal of Biological …, 2004 - ASBMB
The redox poise of the mitochondrial glutathione pool is central in the response of
mitochondria to oxidative damage and redox signaling, but the mechanisms are uncertain.
One possibility is that the oxidation of glutathione (GSH) to glutathione disulfide (GSSG) and
the consequent change in the GSH/GSSG ratio causes protein thiols to change their redox
state, enabling protein function to respond reversibly to redox signals and oxidative damage.
However, little is known about the interplay between the mitochondrial glutathione pool and …
mitochondria to oxidative damage and redox signaling, but the mechanisms are uncertain.
One possibility is that the oxidation of glutathione (GSH) to glutathione disulfide (GSSG) and
the consequent change in the GSH/GSSG ratio causes protein thiols to change their redox
state, enabling protein function to respond reversibly to redox signals and oxidative damage.
However, little is known about the interplay between the mitochondrial glutathione pool and …