[HTML][HTML] Maresin 1 induces a novel pro‐resolving phenotype in human platelets
KL Lannan, SL Spinelli, N Blumberg… - Journal of Thrombosis and …, 2017 - Elsevier
Essentials• Specialized proresolving mediators (SPMs) promote the resolution of
inflammation.• This study sought to investigate the effects of SPMs on human platelet
function.• The SPM, Maresin 1, enhanced hemostatic, but suppressed inflammatory
functions of platelets.• SPMs uniquely regulate platelet function and may represent a new
class of antiplatelet agents. Summary: Background Antiplatelet therapy is a cornerstone of
modern medical practice and is routinely employed to reduce the likelihood of myocardial …
inflammation.• This study sought to investigate the effects of SPMs on human platelet
function.• The SPM, Maresin 1, enhanced hemostatic, but suppressed inflammatory
functions of platelets.• SPMs uniquely regulate platelet function and may represent a new
class of antiplatelet agents. Summary: Background Antiplatelet therapy is a cornerstone of
modern medical practice and is routinely employed to reduce the likelihood of myocardial …