[HTML][HTML] Anti-inflammatory properties of lipoxin A4 protect against diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury
J Han, C Liu, Z Wang, L Liu, L Cheng… - Neural Regeneration …, 2016 - journals.lww.com
Lipoxin A4 can alleviate cerebral ischemia/reperfusion injury by reducing the inflammatory
reaction, but it is currently unclear whether it has a protective effect on diabetes mellitus
complicated by focal cerebral ischemia/reperfusion injury. In this study, we established rat
models of diabetes mellitus using an intraperitoneal injection of streptozotocin. We then
induced focal cerebral ischemia/reperfusion injury by occlusion of the middle cerebral artery
for 2 hours and reperfusion for 24 hours. After administration of lipoxin A4 via the lateral …
reaction, but it is currently unclear whether it has a protective effect on diabetes mellitus
complicated by focal cerebral ischemia/reperfusion injury. In this study, we established rat
models of diabetes mellitus using an intraperitoneal injection of streptozotocin. We then
induced focal cerebral ischemia/reperfusion injury by occlusion of the middle cerebral artery
for 2 hours and reperfusion for 24 hours. After administration of lipoxin A4 via the lateral …