Background: There is no consensus on the treatment of pediatric nonalcoholic fatty liver
disease (NAFLD). However, in a small pilot study conducted in 10 children, metformin has
been proposed to be effective. Objective: We aimed to determine the effect of metformin in
addition to lifestyle intervention/modification in children with NAFLD. Methods: Overweight or
obese children aged 9 to 18 years with biopsy-proven NAFLD or nonalcoholic
steatohepatitis were enrolled in an observational pilot study, initially planned for 12 months …