Manganese superoxide dismutase is reduced in the liver of male but not female humans and rodents with non-alcoholic fatty liver disease
S Krautbauer, K Eisinger, M Lupke, J Wanninger… - … and molecular pathology, 2013 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is among the most common liver diseases.
Oxidative stress is one of the pathogenic mechanisms contributing to the progression of
simple fatty liver to non-alcoholic steatohepatitis (NASH). Manganese superoxide dismutase
(MnSOD) is a mitochondrial antioxidative enzyme and here its expression in rodent and
human NAFLD has been analyzed. MnSOD is found reduced in the liver of male mice fed a
high fat diet and male ob/ob mice. Female mice fed an atherogenic diet to induce NASH …
Oxidative stress is one of the pathogenic mechanisms contributing to the progression of
simple fatty liver to non-alcoholic steatohepatitis (NASH). Manganese superoxide dismutase
(MnSOD) is a mitochondrial antioxidative enzyme and here its expression in rodent and
human NAFLD has been analyzed. MnSOD is found reduced in the liver of male mice fed a
high fat diet and male ob/ob mice. Female mice fed an atherogenic diet to induce NASH …