Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis
J Monsénégo, A Mansouri, M Akkaoui, V Lenoir… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: Despite major public health concern, therapy for non-alcoholic fatty
liver, the liver manifestation of the metabolic syndrome often associated with insulin
resistance (IR), remains elusive. Strategies aiming to decrease liver lipogenesis effectively
corrected hepatic steatosis and IR in obese animals. However, they also indirectly increased
mitochondrial long-chain fatty acid oxidation (mFAO) by decreasing malonyl-CoA, a
lipogenic intermediate, which is the allosteric inhibitor of carnitine palmitoyltransferase 1 …
liver, the liver manifestation of the metabolic syndrome often associated with insulin
resistance (IR), remains elusive. Strategies aiming to decrease liver lipogenesis effectively
corrected hepatic steatosis and IR in obese animals. However, they also indirectly increased
mitochondrial long-chain fatty acid oxidation (mFAO) by decreasing malonyl-CoA, a
lipogenic intermediate, which is the allosteric inhibitor of carnitine palmitoyltransferase 1 …