The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life
S Romeo, F Sentinelli, VM Cambuli, M Incani… - Journal of …, 2010 - Elsevier
BACKGROUND & AIMS: Childhood obesity is a growing problem worldwide. Non-alcoholic
fatty liver disease (NAFLD) is frequently associated with obesity in children. Recently, the
PNPLA3 gene I148M (rs738409) variant was demonstrated to be strongly associated with
hepatic steatosis in obese adults. In this study we add further insight into the role of PNPLA3
by exploring whether this association begins early in life in obese children or becomes
manifest only in adulthood. METHODS: Four hundred and seventy-five obese/overweight …
fatty liver disease (NAFLD) is frequently associated with obesity in children. Recently, the
PNPLA3 gene I148M (rs738409) variant was demonstrated to be strongly associated with
hepatic steatosis in obese adults. In this study we add further insight into the role of PNPLA3
by exploring whether this association begins early in life in obese children or becomes
manifest only in adulthood. METHODS: Four hundred and seventy-five obese/overweight …
