This minireview looks back at a century of glycolysis research with a focus on the
mechanisms of flux regulation. Traditionally, glycolysis is regarded as a feeder pathway that
prepares glucose for further catabolism and energy production. However, glycolysis is much
more than that, in particular in those tissues that express the low affinity glucose-
phosphorylating enzyme glucokinase. This enzyme equips the glycolytic pathway with a
special steering function for the regulation of intermediary metabolism. In beta cells …