Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats
In this paper we analyzed changes in hepatocyte mitochondrial mass and ultrastructure as
well as in mitochondrial markers of fission/fusion and biogenesis in mice subjected to 40%
calorie restriction (CR) for 18 months versus ad libitum-fed controls. Animals subjected to
CR were separated into three groups with different dietary fats: soybean oil (also in controls),
fish oil and lard. Therefore, the effect of the dietary fat under CR was studied as well. Our
results show that CR induced changes in hepatocyte and mitochondrial size, in the volume …
well as in mitochondrial markers of fission/fusion and biogenesis in mice subjected to 40%
calorie restriction (CR) for 18 months versus ad libitum-fed controls. Animals subjected to
CR were separated into three groups with different dietary fats: soybean oil (also in controls),
fish oil and lard. Therefore, the effect of the dietary fat under CR was studied as well. Our
results show that CR induced changes in hepatocyte and mitochondrial size, in the volume …