[PDF][PDF] The metabolic basis of pulmonary arterial hypertension

G Sutendra, ED Michelakis - Cell metabolism, 2014 - cell.com
Cell metabolism, 2014cell.com
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease of the lungs
resulting in heart failure and premature death. Although, until recently, it was thought that
PAH pathology is restricted to pulmonary arteries, several extrapulmonary organs are also
affected. The realization that these tissues share a common metabolic abnormality (ie,
suppression of mitochondrial glucose oxidation and increased glycolysis) is important for
our understanding of PAH, if not a paradigm shift. Here, we discuss an emerging metabolic …
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease of the lungs resulting in heart failure and premature death. Although, until recently, it was thought that PAH pathology is restricted to pulmonary arteries, several extrapulmonary organs are also affected. The realization that these tissues share a common metabolic abnormality (i.e., suppression of mitochondrial glucose oxidation and increased glycolysis) is important for our understanding of PAH, if not a paradigm shift. Here, we discuss an emerging metabolic theory, which proposes that PAH should be viewed as a syndrome involving many organs sharing a mitochondrial abnormality and explains many PAH features and provides novel biomarkers and therapeutic targets.
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