SNAREs—engines for membrane fusion
R Jahn, RH Scheller - Nature reviews Molecular cell biology, 2006 - nature.com
R Jahn, RH Scheller
Nature reviews Molecular cell biology, 2006•nature.comSince the discovery of SNARE proteins in the late 1980s, SNAREs have been recognized as
key components of protein complexes that drive membrane fusion. Despite considerable
sequence divergence among SNARE proteins, their mechanism seems to be conserved and
is adaptable for fusion reactions as diverse as those involved in cell growth, membrane
repair, cytokinesis and synaptic transmission. A fascinating picture of these robust
nanomachines is emerging.
key components of protein complexes that drive membrane fusion. Despite considerable
sequence divergence among SNARE proteins, their mechanism seems to be conserved and
is adaptable for fusion reactions as diverse as those involved in cell growth, membrane
repair, cytokinesis and synaptic transmission. A fascinating picture of these robust
nanomachines is emerging.
Abstract
Since the discovery of SNARE proteins in the late 1980s, SNAREs have been recognized as key components of protein complexes that drive membrane fusion. Despite considerable sequence divergence among SNARE proteins, their mechanism seems to be conserved and is adaptable for fusion reactions as diverse as those involved in cell growth, membrane repair, cytokinesis and synaptic transmission. A fascinating picture of these robust nanomachines is emerging.
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