Increased reactive oxygen species production and functional alterations in antioxidant enzymes in human failing myocardium
F Sam, DL Kerstetter, DR Pimental, S Mulukutla… - Journal of cardiac …, 2005 - Elsevier
BACKGROUND: The nature of oxidative stress and the activity of antioxidant enzyme
systems are incompletely characterized in the failing human heart. METHODS AND
RESULTS: We obtained ventricular myocardium from failing, explanted human hearts in
patients with nonischemic dilated cardiomyopathy at the time of heart transplant to examine
whether reactive oxygen species (ROS) production and antioxidant enzyme activity or
expression were altered in end-stage human heart failure. Nonfailing myocardium was …
systems are incompletely characterized in the failing human heart. METHODS AND
RESULTS: We obtained ventricular myocardium from failing, explanted human hearts in
patients with nonischemic dilated cardiomyopathy at the time of heart transplant to examine
whether reactive oxygen species (ROS) production and antioxidant enzyme activity or
expression were altered in end-stage human heart failure. Nonfailing myocardium was …