Paradoxical roles of cyclin D1 in DNA stability
S Jirawatnotai, G Sittithumcharee - DNA repair, 2016 - Elsevier
Maintenance of DNA integrity is vital for all of the living organisms. Consequence of DNA
damaging ranges from, introducing harmless synonymous mutations, to causing disease-
associated mutations, genome instability, and cell death. A cell cycle protein cyclin D1 is an
established cancer-driving protein. However, contribution of cyclin D1 to cancer formation
and cancer survival is not entirely known. In cancer tissues, overexpression of cyclin D1 is
associated with both cancer genome instability, and resistance to DNA-damaging cancer …
damaging ranges from, introducing harmless synonymous mutations, to causing disease-
associated mutations, genome instability, and cell death. A cell cycle protein cyclin D1 is an
established cancer-driving protein. However, contribution of cyclin D1 to cancer formation
and cancer survival is not entirely known. In cancer tissues, overexpression of cyclin D1 is
associated with both cancer genome instability, and resistance to DNA-damaging cancer …
