[HTML][HTML] A hyaluronan receptor for endocytosis (HARE) link domain N-glycan is required for extracellular signal-regulated kinase (ERK) and nuclear factor-κB (NF-κB) …
MS Pandey, PH Weigel - Journal of Biological Chemistry, 2014 - ASBMB
The human hyaluronan (HA) receptor for endocytosis (HARE; the 190-kDa C terminus of
Stab2) is a major clearance receptor for multiple circulating ligands including HA, heparin
(Hep), acetylated LDL (AcLDL), dermatan sulfate (DS), apoptotic debris, and chondroitin
sulfate types A, C, D, and E. We previously found that HARE contains an N-glycan in the HA
binding Link domain (at Asn 2280), and cells expressing membrane-bound HARE (N2280A)
bind and endocytose HA normally (Harris, EN, Parry, S., Sutton-Smith, M., Pandey, MS …
Stab2) is a major clearance receptor for multiple circulating ligands including HA, heparin
(Hep), acetylated LDL (AcLDL), dermatan sulfate (DS), apoptotic debris, and chondroitin
sulfate types A, C, D, and E. We previously found that HARE contains an N-glycan in the HA
binding Link domain (at Asn 2280), and cells expressing membrane-bound HARE (N2280A)
bind and endocytose HA normally (Harris, EN, Parry, S., Sutton-Smith, M., Pandey, MS …