Metabolic abnormalities and oxidative stress in lupus

YL Lightfoot, LP Blanco, MJ Kaplan - Current Opinion in …, 2017 - journals.lww.com
YL Lightfoot, LP Blanco, MJ Kaplan
Current Opinion in Rheumatology, 2017journals.lww.com
A paucity of knowledge exists regarding the metabolic needs of a number of immune cells
involved in the pathogenesis of SLE, including myeloid cells and B cells. Nonetheless, SLE-
specific metabolic signatures have been identified and their specific targeting, along with
mitochondrial ROS inhibitors/scavengers, could show therapeutic advantage in lupus
patients.
Summary
A paucity of knowledge exists regarding the metabolic needs of a number of immune cells involved in the pathogenesis of SLE, including myeloid cells and B cells. Nonetheless, SLE-specific metabolic signatures have been identified and their specific targeting, along with mitochondrial ROS inhibitors/scavengers, could show therapeutic advantage in lupus patients.
Lippincott Williams & Wilkins