[PDF][PDF] Therapeutic potential of NAD-boosting molecules: the in vivo evidence

L Rajman, K Chwalek, DA Sinclair - Cell metabolism, 2018 - cell.com
Cell metabolism, 2018cell.com
Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is
well known for its role in redox reactions. More recently, it has emerged as a signaling
molecule. By modulating NAD+-sensing enzymes, NAD+ controls hundreds of key
processes from energy metabolism to cell survival, rising and falling depending on food
intake, exercise, and the time of day. NAD+ levels steadily decline with age, resulting in
altered metabolism and increased disease susceptibility. Restoration of NAD+ levels in old …
Summary
Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is well known for its role in redox reactions. More recently, it has emerged as a signaling molecule. By modulating NAD+-sensing enzymes, NAD+ controls hundreds of key processes from energy metabolism to cell survival, rising and falling depending on food intake, exercise, and the time of day. NAD+ levels steadily decline with age, resulting in altered metabolism and increased disease susceptibility. Restoration of NAD+ levels in old or diseased animals can promote health and extend lifespan, prompting a search for safe and efficacious NAD-boosting molecules that hold the promise of increasing the body's resilience, not just to one disease, but to many, thereby extending healthy human lifespan.
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