[HTML][HTML] Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2
Twenty-four hours of fasting is known to blunt activation of the human NLRP3
inflammasome. This effect might be mediated by SIRT3 activation, controlling mitochondrial
reactive oxygen species. To characterize the molecular underpinnings of this fasting effect,
we comparatively analyzed the NLRP3 inflammasome response to nutrient deprivation in
wild-type and SIRT3 knock-out mice. Consistent with previous findings for human NLRP3,
prolonged fasting blunted the inflammasome in wild-type mice but not in SIRT3 knock-out …
inflammasome. This effect might be mediated by SIRT3 activation, controlling mitochondrial
reactive oxygen species. To characterize the molecular underpinnings of this fasting effect,
we comparatively analyzed the NLRP3 inflammasome response to nutrient deprivation in
wild-type and SIRT3 knock-out mice. Consistent with previous findings for human NLRP3,
prolonged fasting blunted the inflammasome in wild-type mice but not in SIRT3 knock-out …
