mRNA transport and local translation in the neuronal dendrite is implicated in the induction
of synaptic plasticity. Recently, we cloned an RNA-interacting protein, SYNCRIP
(heterogeneous nuclear ribonuclear protein Q1/NSAP1), that is suggested to be important
for the stabilization of mRNA. We report here that SYNCRIP is a component of mRNA
granules in rat hippocampal neurons. SYNCRIP was mainly found at cell bodies, but
punctate expression patterns in the proximal dendrite were also seen. Time-lapse analysis …