Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades

AK Hubbard, R Rothlein - Free radical biology and medicine, 2000 - Elsevier
AK Hubbard, R Rothlein
Free radical biology and medicine, 2000Elsevier
The collective interaction between cells is, in part, mediated by different families of adhesion
molecules. Intercellular adhesion molecules (ICAMs) are structurally related members of the
immunoglobulin supergene family and are ligands for the β2 integrin molecules present on
leukocytes. Of the five ICAMs identified, ICAM-1 is the most extensively studied. Although
ICAM-1 is expressed constitutively at low levels on endothelial cells and on some
lymphocytes and monocytes, its expression can be significantly increased in the presence of …
The collective interaction between cells is, in part, mediated by different families of adhesion molecules. Intercellular adhesion molecules (ICAMs) are structurally related members of the immunoglobulin supergene family and are ligands for the β2 integrin molecules present on leukocytes. Of the five ICAMs identified, ICAM-1 is the most extensively studied. Although ICAM-1 is expressed constitutively at low levels on endothelial cells and on some lymphocytes and monocytes, its expression can be significantly increased in the presence of cytokines (TNFα, IL-1, IFNγ) and reactive oxygen species. Depending upon cell type, ICAM-1 participates in trafficking of inflammatory cells, in cell:cell interactions during antigen presentation, in microbial pathogenesis, and in signal transduction through outside-in signaling events. Again, depending upon cell type examined, ICAM-1 engagement has been documented to activate specific kinases through phosphorylation, resulting in transcription factor activation and increased cytokine production, increased cell membrane protein expression, reactive oxygen species production, and cell proliferation.
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