Analysis of concentration-dependent functions of PU. 1 in hematopoiesis using mouse models
RP DeKoter, MB Kamath, IB Houston - Blood Cells, Molecules, and …, 2007 - Elsevier
The Ets family transcription factor PU. 1, encoded by the gene Sfpi1, is essential for normal
hematopoiesis. A number of studies have suggested that changes in PU. 1 concentration
play a role in directing cell fate decisions during hematopoiesis. However, the stages of
hematopoietic development at which changes in PU. 1 concentration are important have not
been defined until recently. Experiments using conditional null alleles, reporter alleles, and
hypomorphic alleles of the Sfpi1 gene in mice demonstrate that PU. 1 concentration is …
hematopoiesis. A number of studies have suggested that changes in PU. 1 concentration
play a role in directing cell fate decisions during hematopoiesis. However, the stages of
hematopoietic development at which changes in PU. 1 concentration are important have not
been defined until recently. Experiments using conditional null alleles, reporter alleles, and
hypomorphic alleles of the Sfpi1 gene in mice demonstrate that PU. 1 concentration is …