Interstitial fibrosis is an important contributor to graft loss in chronic renal allograft injury.
Inflammatory macrophages are associated with fibrosis in renal allografts, but how these
cells contribute to this damaging response is not clearly understood. Here, we investigated
the role of macrophage-to-myofibroblast transition in interstitial fibrosis in human and
experimental chronic renal allograft injury. In biopsy specimens from patients with active
chronic allograft rejection, we identified cells undergoing macrophage-to-myofibroblast …