Kinga Musiał· Danuta Zwolinska received: 10 February 2014/accepted: 13 February 2014/Published online: 5 March 2014© the author (s) 2014. this article is published with open access at Springerlink. com best predictor of tGFbeta1, a hallmark of fibrosis, a fact that is concordant with the tight tIMP–MMP–tGFbeta1 connections described by ries [1]. another interesting aspect of tIMP-1 activity is its anti-apoptotic function, realized by both direct, receptormediated, and indirect, by MMP inhibition, pathways [1]. enhanced apoptosis is one of the key elements in the course of chronic kidney disease, additionally aggravated by the commencement of dialysis. Indeed, our investigation has revealed increased MMP/tIMP concentrations in chronically dialyzed children versus controls [3]. the additional discrepancy between dialysis modalities, most evident in the case of tIMP-1, has strengthened the suggestion that hemodialysis triggers apoptosis and reciprocal anti-apoptotic protection to greater extent than peritoneal dialysis. We have also noticed the statistically significant correlations between markers of matrix turnover and apoptosis [3]. In addition, regression analysis has shown that tIMP-1 was more accurate than tIMP-2, MMP-2, or MMP-9 in the prediction of the well-established apoptotic markers, sFas and sFasL [3]. the abovementioned MMP overactivity and MMP/tIMP imbalance disrupts the integrity of the extracellular matrix in the course of CKD. the subsequent tissue remodeling, together with cell damage and matrix accumulation, gives way to atherosclerosis, renal fibrosis and aggravated cell migration to sites of inflammation. In particular, cells losing their anchorage due to proteolytic overactivity, if not eliminated by anoikis, gain the ability for uncontrolled migration and further metastatic spread. the hallmark of anoikis activity is e-cadherin, released in a circulating form from destroyed cell–cell junctions, and easing epithelial-to-mesenchymal transition (eMt). We have shown for the first time significant correlations between this marker and MMP/tIMP in CKD children,