Increased expressions of TLR2 and TLR4 on peripheral blood mononuclear cells from patients with Alzheimer's disease
W Zhang, LZ Wang, JT Yu, ZF Chi, L Tan - Journal of the neurological …, 2012 - Elsevier
BACKGROUND: Toll-like receptors 2 (TLR2) and TLR4 are involved in the microglia-
mediated inflammatory response, Aβ plaque formation and Aβ clearance in Alzheimer's
disease (AD). Our previous studies have shown that variants in the TLR2 and TLR4 genes
are associated with the risk of AD. Therefore, we hypothesize that there may be significant
changes in TLR2 and TLR4 expressions on peripheral blood mononuclear cells (PBMCs)
from patients with AD when compared to healthy control subjects. METHODS: Sixty patients …
mediated inflammatory response, Aβ plaque formation and Aβ clearance in Alzheimer's
disease (AD). Our previous studies have shown that variants in the TLR2 and TLR4 genes
are associated with the risk of AD. Therefore, we hypothesize that there may be significant
changes in TLR2 and TLR4 expressions on peripheral blood mononuclear cells (PBMCs)
from patients with AD when compared to healthy control subjects. METHODS: Sixty patients …
