Varicella-zoster virus DNA in cells isolated from human trigeminal ganglia
MJ Levin, GY Cai, MD Manchak, LI Pizer - Journal of virology, 2003 - Am Soc Microbiol
MJ Levin, GY Cai, MD Manchak, LI Pizer
Journal of virology, 2003•Am Soc MicrobiolTo determine the type of cell (s) that contain latent varicella-zoster virus (VZV) DNA, we
prepared pure populations of neurons and satellite cells from trigeminal ganglia of 18
humans who had previously had a VZV infection. VZV DNA was present in 34 of 2,226
neurons (1.5%) and in none of 20,700 satellite cells. There was an average of 4.7 (range of
2 to 9) copies of VZV DNA per latently infected neuron. Latent VZV DNA was primarily
present in large neurons, whereas the size distribution of herpes simplex virus DNA was …
prepared pure populations of neurons and satellite cells from trigeminal ganglia of 18
humans who had previously had a VZV infection. VZV DNA was present in 34 of 2,226
neurons (1.5%) and in none of 20,700 satellite cells. There was an average of 4.7 (range of
2 to 9) copies of VZV DNA per latently infected neuron. Latent VZV DNA was primarily
present in large neurons, whereas the size distribution of herpes simplex virus DNA was …
Abstract
To determine the type of cell(s) that contain latent varicella-zoster virus (VZV) DNA, we prepared pure populations of neurons and satellite cells from trigeminal ganglia of 18 humans who had previously had a VZV infection. VZV DNA was present in 34 of 2,226 neurons (1.5%) and in none of 20,700 satellite cells. There was an average of 4.7 (range of 2 to 9) copies of VZV DNA per latently infected neuron. Latent VZV DNA was primarily present in large neurons, whereas the size distribution of herpes simplex virus DNA was markedly different.
American Society for Microbiology