Presence of HIV-1 in human parenchymal and non-parenchymal liver cells in vivo
C Housset, E Lamas, V Courgnaud, O Boucher… - Journal of …, 1993 - Elsevier
The infection of liver cells by HIV-1 was investigated in vivo. Liver biopsies from 13 anti-HIV-
1 antibody-positive patients were studied and HIV-1 DNA was revealed by polymerase
chain reaction (PCR) in eight. In situ hybridization demonstrated the presence of HIV-1 RNA
in all eight PCR-positive liver specimens. Mononuclear inflammatory cells in the portal tracts
and Kupffer cells were labeled by a HIV-1 35 S-RNA probe in all cases and by an anti-p24
monoclonal antibody, in seven cases. In addition, hepatocytes also clearly scored positive …
1 antibody-positive patients were studied and HIV-1 DNA was revealed by polymerase
chain reaction (PCR) in eight. In situ hybridization demonstrated the presence of HIV-1 RNA
in all eight PCR-positive liver specimens. Mononuclear inflammatory cells in the portal tracts
and Kupffer cells were labeled by a HIV-1 35 S-RNA probe in all cases and by an anti-p24
monoclonal antibody, in seven cases. In addition, hepatocytes also clearly scored positive …