Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation
B Bengsch, B Martin, R Thimme - Journal of hepatology, 2014 - Elsevier
Background & Aims The upregulation of several inhibitory signalling pathways by exhausted
HBV-specific CD8+ T cells in chronic infection is thought to contribute to viral persistence.
Blockade of inhibitory receptors to reinvigorate exhausted T cell function is a promising
novel therapeutic approach. However, little information is available regarding the relative
contribution of individual inhibitory pathways to HBV-specific CD8+ T cell failure and the
impact of inhibitory receptor blockade on restoration of T cell function in chronic HBV …
HBV-specific CD8+ T cells in chronic infection is thought to contribute to viral persistence.
Blockade of inhibitory receptors to reinvigorate exhausted T cell function is a promising
novel therapeutic approach. However, little information is available regarding the relative
contribution of individual inhibitory pathways to HBV-specific CD8+ T cell failure and the
impact of inhibitory receptor blockade on restoration of T cell function in chronic HBV …