Current treatments for chronic hepatitis B virus infections
F Zoulim, F Lebossé, M Levrero - Current opinion in Virology, 2016 - Elsevier
Highlights•Chronic hepatitis therapy currently relies on the use of Peg-IFNα, and NUC that
inhibit viral polymerase activity.•Peg-IFNα induces viral load suppression that is sustainable
after treatment cessation in 20% of patients.•NUC administration leads to viral load
suppression in the majority of patients.•Long-term treatment is needed to avoid viral
replication because of the persistence of viral cccDNA in the liver.•Viral load suppression is
associated with a decreased risk of progression of liver disease and hepatocellular …
inhibit viral polymerase activity.•Peg-IFNα induces viral load suppression that is sustainable
after treatment cessation in 20% of patients.•NUC administration leads to viral load
suppression in the majority of patients.•Long-term treatment is needed to avoid viral
replication because of the persistence of viral cccDNA in the liver.•Viral load suppression is
associated with a decreased risk of progression of liver disease and hepatocellular …