Adaptive immunity in HBV infection

A Bertoletti, C Ferrari - Journal of hepatology, 2016 - Elsevier
During hepatitis B virus (HBV) infection, the presence of HBV-specific antibody producing B
cells and functional HBV-specific T cells (with helper or cytotoxic effects) ultimately
determines HBV infection outcome. In this review, in addition to summarizing the present
state of knowledge of HBV-adaptive immunity, we will highlight controversies and
uncertainties concerning the HBV-specific B and T lymphocyte response, and propose future
directions for research aimed at the generation of more efficient immunotherapeutic …