Regulation of human profilaggrin promoter activity in cultured epithelial cells by retinoic acid and glucocorticoids

RB Presland, M Tomic-Canic, SP Lewis… - Journal of dermatological …, 2001 - Elsevier
Vitamin A and other retinoids profoundly inhibit both morphological and biochemical aspects
of epidermal differentiation in vitro. Profilaggrin, like most other markers of keratinocyte
differentiation, is negatively regulated by retinoic acid in vitro, both at the level of mRNA
synthesis and by inhibiting the activity of endoproteases that convert profilaggrin to filaggrin.
Profilaggrin is an abundant component of keratohyalin granules and forms the precursor of
filaggrin, the keratin associated protein of the stratum corneum. In this report, we identify a …