Viral envelope-specific antibodies in chronic hepatitis B virus infection
Highlights•Neutralizing Abs are generated upon infection but mostly not detectable in
chronic disease.•The B cell response in CHB is altered and critical for disease control.•ICs
impede accuracy of actual diagnostics that also miss the detection of Pre-S1Abs.•Envelope-
specific mAbs may be developed for HBV prophylaxis and therapy.While the cellular
immune response associated with acute and chronic HBV infection has been thoroughly
studied, the B cell response in chronic hepatitis B and the role of antibodies raised against …
chronic disease.•The B cell response in CHB is altered and critical for disease control.•ICs
impede accuracy of actual diagnostics that also miss the detection of Pre-S1Abs.•Envelope-
specific mAbs may be developed for HBV prophylaxis and therapy.While the cellular
immune response associated with acute and chronic HBV infection has been thoroughly
studied, the B cell response in chronic hepatitis B and the role of antibodies raised against …