Immune-surveillance through exhausted effector T-cells
D Zehn, DT Utzschneider, R Thimme - Current opinion in virology, 2016 - Elsevier
Highlights•The phenomenon of T-cell exhaustion limits immune responses to persisting
infections.•Nonetheless, these T-cells retain a certain level of function.•We review evidence
that these T-cells mediate a form of immune-surveillance.•Chances and limits linked to using
'exhausted'T-cells for therapies are discussed.Pathogens such as the human
immunodeficiency virus (HIV), the hepatitis B and C virus (HBV, HCV) and certain strains of
the rodent lymphocytic choriomeningitis virus (LCMV) establish a state of persisting viral …
infections.•Nonetheless, these T-cells retain a certain level of function.•We review evidence
that these T-cells mediate a form of immune-surveillance.•Chances and limits linked to using
'exhausted'T-cells for therapies are discussed.Pathogens such as the human
immunodeficiency virus (HIV), the hepatitis B and C virus (HBV, HCV) and certain strains of
the rodent lymphocytic choriomeningitis virus (LCMV) establish a state of persisting viral …