Immunomodulatory molecules are released from the first trimester and term placenta via exosomes
SK Kshirsagar, SM Alam, S Jasti, H Hodes, T Nauser… - Placenta, 2012 - Elsevier
The semiallogenic fetus is tolerated by the maternal immune system through control of
innate and adaptive immune responses. Trophoblast cells secrete nanometer scale
membranous particles called exosomes, which have been implicated in modulation of the
local and systemic maternal immune system. Here we investigate the possibility that
exosomes secreted from the first trimester and term placenta carry HLA-G and B7 family
immunomodulators. Confocal microscopy of placental sections revealed intracellular co …
innate and adaptive immune responses. Trophoblast cells secrete nanometer scale
membranous particles called exosomes, which have been implicated in modulation of the
local and systemic maternal immune system. Here we investigate the possibility that
exosomes secreted from the first trimester and term placenta carry HLA-G and B7 family
immunomodulators. Confocal microscopy of placental sections revealed intracellular co …